American AirlinesDepart19:26
Fri, Nov 13DSM → ORD
1h 47m · Direct
$94one way, per person
View deal
- Cheapest fare
- $94
- Cheapest month
- November
- Direct flights
- Yes
- Flight time
- 1h 39m
American Airlines · Fri, Nov 13
from $94
American Airlines and United Airlines
500 km
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Cheapest month to fly from Des Moines to Chicago
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in November 2026
The lowest fares we've seen for each day, cheapest first.
American Airlines
United AirlinesDepart13:05
Sat, Nov 14DSM → ORD
1h 39m · Direct
$223one way, per person
View deal
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About flights from Des Moines to Chicago
Des Moines (DSM) and Chicago (CHI) are about 500 km apart. Direct flights take around 1h 39m, and recent direct fares were with American Airlines and United Airlines. Over the next few months, one-way fares start from $94, and November 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Des Moines to Chicago?
The cheapest one-way fare we've seen recently is $94 with American Airlines, departing Friday, November 13, 2026.
What is the cheapest month to fly from Des Moines to Chicago?
November 2026 currently has the lowest fares, from $94 one way.
Are there direct flights from Des Moines to Chicago?
Yes. Recent direct fares were with American Airlines and United Airlines.
How long is the flight from Des Moines to Chicago?
A direct flight takes about 1h 39m. Des Moines and Chicago are around 500 km apart.
Which airlines fly from Des Moines to Chicago?
Recent fares on this route were with American Airlines and United Airlines.
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