American AirlinesDepart13:35
Sat, Jul 17DSM → STL
3h 09m · 1 stop
$192one way, per person
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- Cheapest fare
- $192
- Cheapest month
- July
- Direct flights
- Not recently
- Quickest trip
- 3h 07m
American Airlines · Sat, Jul 17
from $192
Usually 1+ stop
440 km
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Cheapest month to fly from Des Moines to St Louis
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in July 2027
The lowest fares we've seen for each day, cheapest first.
American AirlinesPlan the rest of your trip to St Louis
Where to stay, what to do and getting around, from our travel partners.
About flights from Des Moines to St Louis
Des Moines (DSM) and St Louis (STL) are about 440 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 3h 07m. Over the next few months, one-way fares start from $192, and July 2027 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Des Moines to St Louis?
The cheapest one-way fare we've seen recently is $192 with American Airlines, departing Saturday, July 17, 2027. Over the coming months, the lowest fare in each month ranges from $192 to $282.
What is the cheapest month to fly from Des Moines to St Louis?
July 2027 currently has the lowest fares, from $192 one way.
Are there direct flights from Des Moines to St Louis?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Des Moines to St Louis?
The quickest journey we've seen takes about 3h 07m. Des Moines and St Louis are around 440 km apart.
Which airlines fly from Des Moines to St Louis?
Recent fares on this route were with American Airlines.
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