Cheap flights from Manhattan to Knoxville

One-way fares from $446 · MHK → TYS · prices found by travellers in the last 48 hours

Compare all dates Knoxville → Manhattan
Cheapest fare
$446

American Airlines · Sat, Nov 14

Cheapest month
November

from $446

Direct flights
Not recently

Usually 1+ stop

Quickest trip
3h 47m

1,180 km

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Cheapest month to fly from Manhattan to Knoxville

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $446

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

American Airlines
Depart07:06 Sat, Nov 14MHK → TYS 5h 25m · 2 stops
$446one way, per person
View deal
American Airlines
Depart11:00 Fri, Nov 13MHK → TYS 3h 47m · 1 stop
$479one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Knoxville

Where to stay, what to do and getting around, from our travel partners.

Where to stay

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Things to do

Things to do in KnoxvilleTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in KnoxvillePre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in KnoxvilleCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Manhattan to Knoxville

Manhattan (MHK) and Knoxville (TYS) are about 1,180 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 3h 47m. Over the next few months, one-way fares start from $446, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Manhattan to Knoxville?

The cheapest one-way fare we've seen recently is $446 with American Airlines, departing Saturday, November 14, 2026.

What is the cheapest month to fly from Manhattan to Knoxville?

November 2026 currently has the lowest fares, from $446 one way.

Are there direct flights from Manhattan to Knoxville?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Manhattan to Knoxville?

The quickest journey we've seen takes about 3h 47m. Manhattan and Knoxville are around 1,180 km apart.

Which airlines fly from Manhattan to Knoxville?

Recent fares on this route were with American Airlines.

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