Cheap flights from Medford to Greenville

One-way fares from $317 · MFR → GSP · prices found by travellers in the last 48 hours

Cheapest fare
$317

Allegiant Air · Fri, Nov 13

Cheapest month
November

from $317

Direct flights
Not recently

Usually 1+ stop

Quickest trip
8h 47m

3,580 km

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Cheapest month to fly from Medford to Greenville

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $317

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Allegiant Air
Depart21:51 Fri, Nov 13MFR → GSP 8h 47m · 3 stops
$317one way, per person
View deal
See every date in November 2026 →

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About flights from Medford to Greenville

Medford (MFR) and Greenville (GSP) are about 3,580 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 8h 47m. Over the next few months, one-way fares start from $317, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Medford to Greenville?

The cheapest one-way fare we've seen recently is $317 with Allegiant Air, departing Friday, November 13, 2026.

What is the cheapest month to fly from Medford to Greenville?

November 2026 currently has the lowest fares, from $317 one way.

Are there direct flights from Medford to Greenville?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Medford to Greenville?

The quickest journey we've seen takes about 8h 47m. Medford and Greenville are around 3,580 km apart.

Which airlines fly from Medford to Greenville?

Recent fares on this route were with Allegiant Air.

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