Southwest AirlinesDepart07:35
Wed, Nov 25ECP → SFO
7h 10m · 2 stops
$227one way, per person
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- Cheapest fare
- $227
- Cheapest month
- November
- Direct flights
- Not recently
- Quickest trip
- 7h 10m
Southwest Airlines · Wed, Nov 25
from $227
Usually 1+ stop
3,470 km
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Cheapest month to fly from Panama City to San Francisco
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in November 2026
The lowest fares we've seen for each day, cheapest first.
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About flights from Panama City to San Francisco
Panama City (ECP) and San Francisco (SFO) are about 3,470 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 7h 10m. Over the next few months, one-way fares start from $227, and November 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Panama City to San Francisco?
The cheapest one-way fare we've seen recently is $227 with Southwest Airlines, departing Wednesday, November 25, 2026.
What is the cheapest month to fly from Panama City to San Francisco?
November 2026 currently has the lowest fares, from $227 one way.
Are there direct flights from Panama City to San Francisco?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Panama City to San Francisco?
The quickest journey we've seen takes about 7h 10m. Panama City and San Francisco are around 3,470 km apart.
Which airlines fly from Panama City to San Francisco?
Recent fares on this route were with Southwest Airlines.
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