American AirlinesDepart07:02
Sat, Nov 14RST → TYS
6h 37m · 2 stops
$393one way, per person
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- Cheapest fare
- $393
- Cheapest month
- November
- Direct flights
- Not recently
- Quickest trip
- 5h 46m
American Airlines · Sat, Nov 14
from $393
Usually 1+ stop
1,150 km
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Cheapest month to fly from Rochester to Knoxville
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in November 2026
The lowest fares we've seen for each day, cheapest first.
American AirlinesAmerican AirlinesDepart07:02
Fri, Nov 13RST → TYS
5h 46m · 2 stops
$440one way, per person
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About flights from Rochester to Knoxville
Rochester (RST) and Knoxville (TYS) are about 1,150 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 5h 46m. Over the next few months, one-way fares start from $393, and November 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Rochester to Knoxville?
The cheapest one-way fare we've seen recently is $393 with American Airlines, departing Saturday, November 14, 2026.
What is the cheapest month to fly from Rochester to Knoxville?
November 2026 currently has the lowest fares, from $393 one way.
Are there direct flights from Rochester to Knoxville?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Rochester to Knoxville?
The quickest journey we've seen takes about 5h 46m. Rochester and Knoxville are around 1,150 km apart.
Which airlines fly from Rochester to Knoxville?
Recent fares on this route were with American Airlines.
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