Cheap flights from Tupelo to Knoxville

One-way fares from $293 · TUP → TYS · prices found by travellers in the last 48 hours

Compare all dates Knoxville → Tupelo
Cheapest fare
$293

Contour Airlines · Fri, Nov 13

Cheapest month
November

from $293

Direct flights
Not recently

Usually 1+ stop

Quickest trip
4h 56m

480 km

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Cheapest month to fly from Tupelo to Knoxville

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $293

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Contour Airlines
Depart08:00 Fri, Nov 13TUP → TYS 4h 56m · 2 stops
$293one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Knoxville

Where to stay, what to do and getting around, from our travel partners.

Where to stay

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Things to do

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Getting around

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About flights from Tupelo to Knoxville

Tupelo (TUP) and Knoxville (TYS) are about 480 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 4h 56m. Over the next few months, one-way fares start from $293, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Tupelo to Knoxville?

The cheapest one-way fare we've seen recently is $293 with Contour Airlines, departing Friday, November 13, 2026.

What is the cheapest month to fly from Tupelo to Knoxville?

November 2026 currently has the lowest fares, from $293 one way.

Are there direct flights from Tupelo to Knoxville?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Tupelo to Knoxville?

The quickest journey we've seen takes about 4h 56m. Tupelo and Knoxville are around 480 km apart.

Which airlines fly from Tupelo to Knoxville?

Recent fares on this route were with Contour Airlines.

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