LATAM Airlines GroupDepart15:55
Sun, Dec 27CLO → GYE
3h 59m · 2 stops
$242one way, per person
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- Cheapest fare
- $242
- Cheapest month
- December
- Direct flights
- Not recently
- Quickest trip
- 3h 43m
LATAM Airlines Group · Sun, Dec 27
from $242
Usually 1+ stop
730 km
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Cheapest month to fly from Cali to Guayaquil
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in December 2026
The lowest fares we've seen for each day, cheapest first.
LATAM Airlines GroupLATAM Airlines GroupDepart05:35
Mon, Dec 28CLO → GYE
3h 43m · 2 stops
$242one way, per person
View deal
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About flights from Cali to Guayaquil
Cali (CLO) and Guayaquil (GYE) are about 730 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 3h 43m. Over the next few months, one-way fares start from $242, and December 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Cali to Guayaquil?
The cheapest one-way fare we've seen recently is $242 with LATAM Airlines Group, departing Sunday, December 27, 2026. Over the coming months, the lowest fare in each month ranges from $242 to $244.
What is the cheapest month to fly from Cali to Guayaquil?
December 2026 currently has the lowest fares, from $242 one way.
Are there direct flights from Cali to Guayaquil?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Cali to Guayaquil?
The quickest journey we've seen takes about 3h 43m. Cali and Guayaquil are around 730 km apart.
Which airlines fly from Cali to Guayaquil?
Recent fares on this route were with LATAM Airlines Group.