Cheap flights from Madrid to Panama City

One-way fares from €291 · MAD → PTY · prices found by travellers in the last 48 hours

Compare all dates Panama City → Madrid
Cheapest fare
€291

avianca airlines · Thu, 15 Apr

Cheapest month
April

from €291

Direct flights
Yes

Air Europa

Flight time
10h 35m

8,160 km

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Cheapest month to fly from Madrid to Panama City

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 €466
  2. December 2026 €574
  3. March 2027 €303
  4. April 2027 Cheapest €291

Cheapest dates in April 2027

The lowest fares we've seen for each day, cheapest first.

avianca airlines
Depart17:20 Thu, 15 AprMAD → PTY 11h 55m · 1 stop
€291one way, per person
View deal
See every date in April 2027 →

Plan the rest of your trip to Panama City

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in Panama CityCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in Panama CityTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in Panama CityPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Panama CityCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Madrid to Panama City

Madrid (MAD) and Panama City (PTY) are about 8,160 km apart. Direct flights take around 10h 35m, and recent direct fares were with Air Europa. Over the next few months, one-way fares start from €291, and April 2027 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Madrid to Panama City?

The cheapest one-way fare we've seen recently is €291 with avianca airlines, departing Thursday, 15 April 2027. Over the coming months, the lowest fare in each month ranges from €291 to €574.

What is the cheapest month to fly from Madrid to Panama City?

April 2027 currently has the lowest fares, from €291 one way.

Are there direct flights from Madrid to Panama City?

Yes. Recent direct fares were with Air Europa.

How long is the flight from Madrid to Panama City?

A direct flight takes about 10h 35m. Madrid and Panama City are around 8,160 km apart.

Which airlines fly from Madrid to Panama City?

Recent fares on this route were with Iberia, Air Europa and avianca airlines.

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