Cheap flights from Panama City to Madrid

One-way fares from $513 · PTY → MAD · prices found by travellers in the last 48 hours

Cheapest fare
$513

Air Europa · Sun, Nov 22

Cheapest month
November

from $513

Direct flights
Yes

Air Europa

Flight time
9h 35m

8,160 km

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Cheapest month to fly from Panama City to Madrid

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $513
  2. December 2026 $575
  3. January 2027 $761
  4. June 2027 $664

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Air Europa
Depart21:30 Sun, Nov 22PTY → MAD 9h 35m · Direct
$513one way, per person
View deal
Air Europa
Depart21:30 Wed, Nov 18PTY → MAD 9h 35m · Direct
$594one way, per person
View deal
Air Europa
Depart21:30 Thu, Nov 19PTY → MAD 9h 35m · Direct
$597one way, per person
View deal
Air Europa
Depart21:30 Fri, Nov 20PTY → MAD 9h 35m · Direct
$700one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Madrid

Where to stay, what to do and getting around, from our travel partners.

About flights from Panama City to Madrid

Panama City (PTY) and Madrid (MAD) are about 8,160 km apart. Direct flights take around 9h 35m, and recent direct fares were with Air Europa. Over the next few months, one-way fares start from $513, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Panama City to Madrid?

The cheapest one-way fare we've seen recently is $513 with Air Europa, departing Sunday, November 22, 2026. Over the coming months, the lowest fare in each month ranges from $513 to $761.

What is the cheapest month to fly from Panama City to Madrid?

November 2026 currently has the lowest fares, from $513 one way.

Are there direct flights from Panama City to Madrid?

Yes. Recent direct fares were with Air Europa.

How long is the flight from Panama City to Madrid?

A direct flight takes about 9h 35m. Panama City and Madrid are around 8,160 km apart.

Which airlines fly from Panama City to Madrid?

Recent fares on this route were with Air Europa, Copa Airlines and avianca airlines.

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