Cheap flights from Medellin to Panama City

One-way fares from $264 · MDE → PTY · prices found by travellers in the last 48 hours

Compare all dates Panama City → Medellin
Cheapest fare
$264

avianca airlines · Thu, Nov 26

Cheapest month
November

from $264

Direct flights
Not recently

Usually 1+ stop

Quickest trip
2h 35m

530 km

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Cheapest month to fly from Medellin to Panama City

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $264
  2. December 2026 $269
  3. January 2027 $296
  4. February 2027 $278
  5. May 2027 $282
  6. September 2027 $293

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

avianca airlines
Depart20:40 Thu, Nov 26MDE → PTY 2h 40m · 1 stop
$264one way, per person
View deal
avianca airlines
Depart10:45 Sun, Nov 8MDE → PTY 2h 40m · 1 stop
$269one way, per person
View deal
avianca airlines
Depart12:40 Sun, Nov 15MDE → PTY 2h 40m · 1 stop
$273one way, per person
View deal
avianca airlines
Depart20:40 Tue, Nov 3MDE → PTY 2h 40m · 1 stop
$286one way, per person
View deal
avianca airlines
Depart10:20 Thu, Nov 5MDE → PTY 2h 50m · 1 stop
$293one way, per person
View deal
avianca airlines
Depart20:40 Fri, Nov 6MDE → PTY 2h 45m · 1 stop
$293one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Panama City

Where to stay, what to do and getting around, from our travel partners.

Where to stay

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Things to do

Things to do in Panama CityTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in Panama CityPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Panama CityCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Medellin to Panama City

Medellin (MDE) and Panama City (PTY) are about 530 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 2h 35m. Over the next few months, one-way fares start from $264, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Medellin to Panama City?

The cheapest one-way fare we've seen recently is $264 with avianca airlines, departing Thursday, November 26, 2026. Over the coming months, the lowest fare in each month ranges from $264 to $296.

What is the cheapest month to fly from Medellin to Panama City?

November 2026 currently has the lowest fares, from $264 one way.

Are there direct flights from Medellin to Panama City?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Medellin to Panama City?

The quickest journey we've seen takes about 2h 35m. Medellin and Panama City are around 530 km apart.

Which airlines fly from Medellin to Panama City?

Recent fares on this route were with avianca airlines.

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