Cheap flights from Medellin to Sao Paulo

One-way fares from $350 · MDE → SAO · prices found by travellers in the last 48 hours

Compare all dates Sao Paulo → Medellin
Cheapest fare
$350

LATAM Airlines Group · Sun, Nov 15

Cheapest month
November

from $350

Direct flights
Not recently

Usually 1+ stop

Quickest trip
7h 20m

4,570 km

Get a price alert

We'll email you when Medellin → Sao Paulo drops to your price. It's free, and you can stop any time.

Today's cheapest fare is $350. We'll send one email to confirm. See our privacy policy.

Cheapest month to fly from Medellin to Sao Paulo

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $350
  2. December 2026 $360
  3. March 2027 $355
  4. July 2027 $373

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

LATAM Airlines Group
Depart05:35 Sun, Nov 15MDE → GRU 7h 30m · 1 stop
$350one way, per person
View deal
LATAM Airlines Group
Depart18:10 Mon, Nov 30MDE → GRU 8h 25m · 1 stop
$361one way, per person
View deal
LATAM Airlines Group
Depart05:35 Thu, Nov 26MDE → GRU 7h 30m · 1 stop
$365one way, per person
View deal
Copa Airlines
Depart10:45 Mon, Nov 9MDE → GRU 8h 18m · 1 stop
$376one way, per person
View deal
Copa Airlines
Depart08:35 Fri, Nov 6MDE → GRU 8h 18m · 1 stop
$385one way, per person
View deal
Copa Airlines
Depart15:15 Wed, Nov 4MDE → GRU 8h 19m · 1 stop
$398one way, per person
View deal
LATAM Airlines Group
Depart09:45 Sun, Nov 8MDE → GRU 7h 20m · 1 stop
$431one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Sao Paulo

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in Sao PauloCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in Sao PauloTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in Sao PauloPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Sao PauloCompare rental cars from major brands on EconomyBookings Compare cars →

Stay connected

eSIM for BrazilMobile data from the moment you land, by Airalo Get eSIM →

About flights from Medellin to Sao Paulo

Medellin (MDE) and Sao Paulo (SAO) are about 4,570 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 7h 20m. Over the next few months, one-way fares start from $350, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Medellin to Sao Paulo?

The cheapest one-way fare we've seen recently is $350 with LATAM Airlines Group, departing Sunday, November 15, 2026. Over the coming months, the lowest fare in each month ranges from $350 to $373.

What is the cheapest month to fly from Medellin to Sao Paulo?

November 2026 currently has the lowest fares, from $350 one way.

Are there direct flights from Medellin to Sao Paulo?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Medellin to Sao Paulo?

The quickest journey we've seen takes about 7h 20m. Medellin and Sao Paulo are around 4,570 km apart.

Which airlines fly from Medellin to Sao Paulo?

Recent fares on this route were with LATAM Airlines Group, JetSmart and Copa Airlines.

More cheap flights from Medellin

Compare flights to Sao Paulo from other cities →