Cheap flights from Panama City to Guatemala City

One-way fares from $351 · ECP → GUA · prices found by travellers in the last 48 hours

Compare all dates Guatemala City → Panama City
Cheapest fare
$351

American Airlines · Mon, Feb 8

Cheapest month
February

from $351

Direct flights
Not recently

Usually 1+ stop

Quickest trip
6h 44m

1,800 km

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Cheapest month to fly from Panama City to Guatemala City

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 $573
  2. February 2027 Cheapest $351

Cheapest dates in February 2027

The lowest fares we've seen for each day, cheapest first.

American Airlines
Depart17:59 Mon, Feb 8ECP → GUA 7h 02m · 2 stops
$351one way, per person
View deal
See every date in February 2027 →

Plan the rest of your trip to Guatemala City

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in Guatemala CityCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in Guatemala CityTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in Guatemala CityPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Guatemala CityCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Panama City to Guatemala City

Panama City (ECP) and Guatemala City (GUA) are about 1,800 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 6h 44m. Over the next few months, one-way fares start from $351, and February 2027 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Panama City to Guatemala City?

The cheapest one-way fare we've seen recently is $351 with American Airlines, departing Monday, February 8, 2027. Over the coming months, the lowest fare in each month ranges from $351 to $573.

What is the cheapest month to fly from Panama City to Guatemala City?

February 2027 currently has the lowest fares, from $351 one way.

Are there direct flights from Panama City to Guatemala City?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Panama City to Guatemala City?

The quickest journey we've seen takes about 6h 44m. Panama City and Guatemala City are around 1,800 km apart.

Which airlines fly from Panama City to Guatemala City?

Recent fares on this route were with American Airlines.

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