American AirlinesDepart07:10
Thu, Nov 12ECP → TYS
3h 09m · 1 stop
$326one way, per person
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- Cheapest fare
- $326
- Cheapest month
- November
- Direct flights
- Not recently
- Quickest trip
- 3h 09m
American Airlines · Thu, Nov 12
from $326
Usually 1+ stop
660 km
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Cheapest month to fly from Panama City to Knoxville
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in November 2026
The lowest fares we've seen for each day, cheapest first.
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About flights from Panama City to Knoxville
Panama City (ECP) and Knoxville (TYS) are about 660 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 3h 09m. Over the next few months, one-way fares start from $326, and November 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Panama City to Knoxville?
The cheapest one-way fare we've seen recently is $326 with American Airlines, departing Thursday, November 12, 2026.
What is the cheapest month to fly from Panama City to Knoxville?
November 2026 currently has the lowest fares, from $326 one way.
Are there direct flights from Panama City to Knoxville?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Panama City to Knoxville?
The quickest journey we've seen takes about 3h 09m. Panama City and Knoxville are around 660 km apart.
Which airlines fly from Panama City to Knoxville?
Recent fares on this route were with American Airlines.
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