Cheap flights from Quito to Santa Cruz

One-way fares from $437 · UIO → SRZ · prices found by travellers in the last 48 hours

Compare all dates Santa Cruz → Quito
Cheapest fare
$437

JetSmart · Fri, Dec 25

Cheapest month
December

from $437

Direct flights
Not recently

Usually 1+ stop

Quickest trip
4h 55m

2,580 km

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Cheapest month to fly from Quito to Santa Cruz

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. December 2026 Cheapest $437

Cheapest dates in December 2026

The lowest fares we've seen for each day, cheapest first.

JetSmart
Depart16:50 Fri, Dec 25UIO → VVI 4h 55m · 1 stop
$437one way, per person
View deal
See every date in December 2026 →

Plan the rest of your trip to Santa Cruz

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in Santa CruzCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in Santa CruzTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in Santa CruzPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Santa CruzCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Quito to Santa Cruz

Quito (UIO) and Santa Cruz (SRZ) are about 2,580 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 4h 55m. Over the next few months, one-way fares start from $437, and December 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Quito to Santa Cruz?

The cheapest one-way fare we've seen recently is $437 with JetSmart, departing Friday, December 25, 2026.

What is the cheapest month to fly from Quito to Santa Cruz?

December 2026 currently has the lowest fares, from $437 one way.

Are there direct flights from Quito to Santa Cruz?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Quito to Santa Cruz?

The quickest journey we've seen takes about 4h 55m. Quito and Santa Cruz are around 2,580 km apart.

Which airlines fly from Quito to Santa Cruz?

Recent fares on this route were with JetSmart.

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