Cheap flights from Santa Cruz to Quito

One-way fares from $434 · SRZ → UIO · prices found by travellers in the last 48 hours

Cheapest fare
$434

LATAM Airlines Group · Mon, Apr 19

Cheapest month
April

from $434

Direct flights
Not recently

Usually 1+ stop

Quickest trip
5h 25m

2,580 km

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Cheapest month to fly from Santa Cruz to Quito

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 $463
  2. April 2027 Cheapest $434

Cheapest dates in April 2027

The lowest fares we've seen for each day, cheapest first.

LATAM Airlines Group
Depart05:30 Mon, Apr 19VVI → UIO 5h 46m · 2 stops
$434one way, per person
View deal
Boliviana de Aviación
Depart20:55 Tue, Apr 20VVI → UIO 5h 25m · 2 stops
$445one way, per person
View deal
Copa Airlines
Depart09:56 Wed, Apr 21VVI → UIO 6h 55m · 1 stop
$491one way, per person
View deal
See every date in April 2027 →

Plan the rest of your trip to Quito

Where to stay, what to do and getting around, from our travel partners.

About flights from Santa Cruz to Quito

Santa Cruz (SRZ) and Quito (UIO) are about 2,580 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 5h 25m. Over the next few months, one-way fares start from $434, and April 2027 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santa Cruz to Quito?

The cheapest one-way fare we've seen recently is $434 with LATAM Airlines Group, departing Monday, April 19, 2027. Over the coming months, the lowest fare in each month ranges from $434 to $463.

What is the cheapest month to fly from Santa Cruz to Quito?

April 2027 currently has the lowest fares, from $434 one way.

Are there direct flights from Santa Cruz to Quito?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Santa Cruz to Quito?

The quickest journey we've seen takes about 5h 25m. Santa Cruz and Quito are around 2,580 km apart.

Which airlines fly from Santa Cruz to Quito?

Recent fares on this route were with Copa Airlines, LATAM Airlines Group and Boliviana de Aviación.

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