LATAM Airlines GroupDepart20:25
Wed, Nov 25SCL → GYE
5h 55m · 1 stop
$251one way, per person
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- Cheapest fare
- $251
- Cheapest month
- November
- Direct flights
- Not recently
- Quickest trip
- 5h 55m
LATAM Airlines Group · Wed, Nov 25
from $251
Usually 1+ stop
3,610 km
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Cheapest month to fly from Santiago to Guayaquil
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in November 2026
The lowest fares we've seen for each day, cheapest first.
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Where to stay, what to do and getting around, from our travel partners.
About flights from Santiago to Guayaquil
Santiago (SCL) and Guayaquil (GYE) are about 3,610 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 5h 55m. Over the next few months, one-way fares start from $251, and November 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Santiago to Guayaquil?
The cheapest one-way fare we've seen recently is $251 with LATAM Airlines Group, departing Wednesday, November 25, 2026.
What is the cheapest month to fly from Santiago to Guayaquil?
November 2026 currently has the lowest fares, from $251 one way.
Are there direct flights from Santiago to Guayaquil?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Santiago to Guayaquil?
The quickest journey we've seen takes about 5h 55m. Santiago and Guayaquil are around 3,610 km apart.
Which airlines fly from Santiago to Guayaquil?
Recent fares on this route were with LATAM Airlines Group.
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