Cheap flights from Guayaquil to Santiago

One-way fares from $228 · GYE → SCL · prices found by travellers in the last 48 hours

Compare all dates Santiago → Guayaquil
Cheapest fare
$228

LATAM Airlines Group · Fri, Dec 4

Cheapest month
December

from $228

Direct flights
Not recently

Usually 1+ stop

Quickest trip
5h 20m

3,610 km

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Cheapest month to fly from Guayaquil to Santiago

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 $262
  2. December 2026 Cheapest $228
  3. February 2027 $229

Cheapest dates in December 2026

The lowest fares we've seen for each day, cheapest first.

LATAM Airlines Group
Depart09:10 Fri, Dec 4GYE → SCL 5h 25m · 1 stop
$228one way, per person
View deal
LATAM Airlines Group
Depart09:10 Sat, Dec 5GYE → SCL 5h 25m · 1 stop
$239one way, per person
View deal
See every date in December 2026 →

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About flights from Guayaquil to Santiago

Guayaquil (GYE) and Santiago (SCL) are about 3,610 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 5h 20m. Over the next few months, one-way fares start from $228, and December 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Guayaquil to Santiago?

The cheapest one-way fare we've seen recently is $228 with LATAM Airlines Group, departing Friday, December 4, 2026. Over the coming months, the lowest fare in each month ranges from $228 to $262.

What is the cheapest month to fly from Guayaquil to Santiago?

December 2026 currently has the lowest fares, from $228 one way.

Are there direct flights from Guayaquil to Santiago?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Guayaquil to Santiago?

The quickest journey we've seen takes about 5h 20m. Guayaquil and Santiago are around 3,610 km apart.

Which airlines fly from Guayaquil to Santiago?

Recent fares on this route were with LATAM Airlines Group.

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