Cheap flights from Santiago to La Serena

One-way fares from $24 · SCL → LSC · prices found by travellers in the last 48 hours

Compare all dates La Serena → Santiago
Cheapest fare
$24

JetSmart · Fri, Dec 18

Cheapest month
December

from $24

Direct flights
Yes

Sky Airline and JetSmart

Flight time
1h 09m

400 km

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Cheapest month to fly from Santiago to La Serena

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 $29
  2. December 2026 Cheapest $24

Cheapest dates in December 2026

The lowest fares we've seen for each day, cheapest first.

JetSmart
Depart08:17 Fri, Dec 18SCL → LSC 1h 09m · Direct
$24one way, per person
View deal
JetSmart
Depart08:41 Sun, Dec 20SCL → LSC 1h 09m · Direct
$24one way, per person
View deal
See every date in December 2026 →

Plan the rest of your trip to La Serena

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in La SerenaCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in La SerenaTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in La SerenaPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in La SerenaCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Santiago to La Serena

Santiago (SCL) and La Serena (LSC) are about 400 km apart. Direct flights take around 1h 09m, and recent direct fares were with Sky Airline and JetSmart. Over the next few months, one-way fares start from $24, and December 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santiago to La Serena?

The cheapest one-way fare we've seen recently is $24 with JetSmart, departing Friday, December 18, 2026. Over the coming months, the lowest fare in each month ranges from $24 to $29.

What is the cheapest month to fly from Santiago to La Serena?

December 2026 currently has the lowest fares, from $24 one way.

Are there direct flights from Santiago to La Serena?

Yes. Recent direct fares were with Sky Airline and JetSmart.

How long is the flight from Santiago to La Serena?

A direct flight takes about 1h 09m. Santiago and La Serena are around 400 km apart.

Which airlines fly from Santiago to La Serena?

Recent fares on this route were with Sky Airline and JetSmart.

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