Cheap flights from Santiago to Medellin

One-way fares from $209 · SCL → MDE · prices found by travellers in the last 48 hours

Compare all dates Medellin → Santiago
Cheapest fare
$209

JetSmart · Fri, Jan 1

Cheapest month
January

from $209

Direct flights
Yes

JetSmart

Flight time
6h 15m

4,440 km

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Cheapest month to fly from Santiago to Medellin

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. December 2026 $235
  2. January 2027 Cheapest $209

Cheapest dates in January 2027

The lowest fares we've seen for each day, cheapest first.

JetSmart
Depart02:13 Fri, Jan 1SCL → MDE 6h 15m · Direct
$209one way, per person
View deal
LATAM Airlines Group
Depart04:10 Sat, Jan 2SCL → MDE 7h 05m · 1 stop
$218one way, per person
View deal
JetSmart
Depart02:13 Sun, Jan 3SCL → MDE 6h 15m · Direct
$237one way, per person
View deal
See every date in January 2027 →

Plan the rest of your trip to Medellin

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in MedellinCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in MedellinTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in MedellinPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in MedellinCompare rental cars from major brands on EconomyBookings Compare cars →

Stay connected

eSIM for ColombiaMobile data from the moment you land, by Airalo Get eSIM →

About flights from Santiago to Medellin

Santiago (SCL) and Medellin (MDE) are about 4,440 km apart. Direct flights take around 6h 15m, and recent direct fares were with JetSmart. Over the next few months, one-way fares start from $209, and January 2027 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santiago to Medellin?

The cheapest one-way fare we've seen recently is $209 with JetSmart, departing Friday, January 1, 2027. Over the coming months, the lowest fare in each month ranges from $209 to $235.

What is the cheapest month to fly from Santiago to Medellin?

January 2027 currently has the lowest fares, from $209 one way.

Are there direct flights from Santiago to Medellin?

Yes. Recent direct fares were with JetSmart.

How long is the flight from Santiago to Medellin?

A direct flight takes about 6h 15m. Santiago and Medellin are around 4,440 km apart.

Which airlines fly from Santiago to Medellin?

Recent fares on this route were with JetSmart and LATAM Airlines Group.

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