Cheap flights from Medellin to Santiago

One-way fares from $208 · MDE → SCL · prices found by travellers in the last 48 hours

Compare all dates Santiago → Medellin
Cheapest fare
$208

JetSmart · Thu, Dec 3

Cheapest month
December

from $208

Direct flights
Yes

JetSmart

Flight time
6h 12m

4,440 km

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Cheapest month to fly from Medellin to Santiago

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 $258
  2. December 2026 Cheapest $208
  3. January 2027 $289

Cheapest dates in December 2026

The lowest fares we've seen for each day, cheapest first.

JetSmart
Depart17:01 Thu, Dec 3MDE → SCL 6h 12m · Direct
$208one way, per person
View deal
JetSmart
Depart17:01 Fri, Dec 4MDE → SCL 6h 12m · Direct
$208one way, per person
View deal
JetSmart
Depart17:01 Thu, Dec 31MDE → SCL 6h 12m · Direct
$232one way, per person
View deal
JetSmart
Depart17:36 Wed, Dec 2MDE → SCL 6h 44m · 1 stop
$242one way, per person
View deal
See every date in December 2026 →

Plan the rest of your trip to Santiago

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in SantiagoCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in SantiagoTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in SantiagoPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in SantiagoCompare rental cars from major brands on EconomyBookings Compare cars →

Stay connected

eSIM for ChileMobile data from the moment you land, by Airalo Get eSIM →

About flights from Medellin to Santiago

Medellin (MDE) and Santiago (SCL) are about 4,440 km apart. Direct flights take around 6h 12m, and recent direct fares were with JetSmart. Over the next few months, one-way fares start from $208, and December 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Medellin to Santiago?

The cheapest one-way fare we've seen recently is $208 with JetSmart, departing Thursday, December 3, 2026. Over the coming months, the lowest fare in each month ranges from $208 to $289.

What is the cheapest month to fly from Medellin to Santiago?

December 2026 currently has the lowest fares, from $208 one way.

Are there direct flights from Medellin to Santiago?

Yes. Recent direct fares were with JetSmart.

How long is the flight from Medellin to Santiago?

A direct flight takes about 6h 12m. Medellin and Santiago are around 4,440 km apart.

Which airlines fly from Medellin to Santiago?

Recent fares on this route were with LATAM Airlines Group and JetSmart.

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