Cheap flights from Santiago to Santa Cruz

One-way fares from $206 · SCL → SRZ · prices found by travellers in the last 48 hours

Compare all dates Santa Cruz → Santiago
Cheapest fare
$206

Boliviana de Aviación · Wed, Feb 3

Cheapest month
February

from $206

Direct flights
Yes

Boliviana de Aviación

Flight time
3h 15m

1,890 km

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Cheapest month to fly from Santiago to Santa Cruz

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. February 2027 Cheapest $206

Cheapest dates in February 2027

The lowest fares we've seen for each day, cheapest first.

Boliviana de Aviación
Depart02:25 Wed, Feb 3SCL → VVI 3h 15m · Direct
$206one way, per person
View deal
See every date in February 2027 →

Plan the rest of your trip to Santa Cruz

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in Santa CruzCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in Santa CruzTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in Santa CruzPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Santa CruzCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Santiago to Santa Cruz

Santiago (SCL) and Santa Cruz (SRZ) are about 1,890 km apart. Direct flights take around 3h 15m, and recent direct fares were with Boliviana de Aviación. Over the next few months, one-way fares start from $206, and February 2027 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santiago to Santa Cruz?

The cheapest one-way fare we've seen recently is $206 with Boliviana de Aviación, departing Wednesday, February 3, 2027.

What is the cheapest month to fly from Santiago to Santa Cruz?

February 2027 currently has the lowest fares, from $206 one way.

Are there direct flights from Santiago to Santa Cruz?

Yes. Recent direct fares were with Boliviana de Aviación.

How long is the flight from Santiago to Santa Cruz?

A direct flight takes about 3h 15m. Santiago and Santa Cruz are around 1,890 km apart.

Which airlines fly from Santiago to Santa Cruz?

Recent fares on this route were with Boliviana de Aviación.

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