Cheap flights from Santa Cruz to Santiago

One-way fares from $205 · SRZ → SCL · prices found by travellers in the last 48 hours

Compare all dates Santiago → Santa Cruz
Cheapest fare
$205

Boliviana de Aviación · Tue, May 11

Cheapest month
May

from $205

Direct flights
Yes

Boliviana de Aviación

Flight time
3h 15m

1,890 km

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Cheapest month to fly from Santa Cruz to Santiago

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 $235
  2. December 2026 $242
  3. May 2027 Cheapest $205

Cheapest dates in May 2027

The lowest fares we've seen for each day, cheapest first.

Boliviana de Aviación
Depart21:15 Tue, May 11VVI → SCL 3h 15m · Direct
$205one way, per person
View deal
See every date in May 2027 →

Plan the rest of your trip to Santiago

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in SantiagoCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in SantiagoTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in SantiagoPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in SantiagoCompare rental cars from major brands on EconomyBookings Compare cars →

Stay connected

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About flights from Santa Cruz to Santiago

Santa Cruz (SRZ) and Santiago (SCL) are about 1,890 km apart. Direct flights take around 3h 15m, and recent direct fares were with Boliviana de Aviación. Over the next few months, one-way fares start from $205, and May 2027 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santa Cruz to Santiago?

The cheapest one-way fare we've seen recently is $205 with Boliviana de Aviación, departing Tuesday, May 11, 2027. Over the coming months, the lowest fare in each month ranges from $205 to $242.

What is the cheapest month to fly from Santa Cruz to Santiago?

May 2027 currently has the lowest fares, from $205 one way.

Are there direct flights from Santa Cruz to Santiago?

Yes. Recent direct fares were with Boliviana de Aviación.

How long is the flight from Santa Cruz to Santiago?

A direct flight takes about 3h 15m. Santa Cruz and Santiago are around 1,890 km apart.

Which airlines fly from Santa Cruz to Santiago?

Recent fares on this route were with Boliviana de Aviación.

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