Cheap flights from Santo Domingo to Sao Paulo

One-way fares from $453 · SDQ → SAO · prices found by travellers in the last 48 hours

Compare all dates Sao Paulo → Santo Domingo
Cheapest fare
$453

Copa Airlines · Wed, Nov 4

Cheapest month
November

from $453

Direct flights
Not recently

Usually 1+ stop

Quickest trip
8h 50m

5,310 km

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Cheapest month to fly from Santo Domingo to Sao Paulo

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $453
  2. January 2027 $548

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Copa Airlines
Depart14:20 Wed, Nov 4SDQ → GRU 9h 23m · 1 stop
$453one way, per person
View deal
Copa Airlines
Depart12:45 Thu, Nov 5SDQ → GRU 9h 25m · 1 stop
$453one way, per person
View deal
Copa Airlines
Depart12:10 Sat, Nov 7SDQ → GRU 9h 24m · 1 stop
$453one way, per person
View deal
avianca airlines
Depart12:45 Fri, Nov 6SDQ → GRU 8h 50m · 1 stop
$530one way, per person
View deal
See every date in November 2026 →

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About flights from Santo Domingo to Sao Paulo

Santo Domingo (SDQ) and Sao Paulo (SAO) are about 5,310 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 8h 50m. Over the next few months, one-way fares start from $453, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santo Domingo to Sao Paulo?

The cheapest one-way fare we've seen recently is $453 with Copa Airlines, departing Wednesday, November 4, 2026. Over the coming months, the lowest fare in each month ranges from $453 to $548.

What is the cheapest month to fly from Santo Domingo to Sao Paulo?

November 2026 currently has the lowest fares, from $453 one way.

Are there direct flights from Santo Domingo to Sao Paulo?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Santo Domingo to Sao Paulo?

The quickest journey we've seen takes about 8h 50m. Santo Domingo and Sao Paulo are around 5,310 km apart.

Which airlines fly from Santo Domingo to Sao Paulo?

Recent fares on this route were with Copa Airlines and avianca airlines.

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