Cheap flights from Medellin to Cusco

One-way fares from $219 · MDE → CUZ · prices found by travellers in the last 48 hours

Compare all dates Cusco → Medellin
Cheapest fare
$219

JetSmart · Tue, Apr 27

Cheapest month
April

from $219

Direct flights
Not recently

Usually 1+ stop

Quickest trip
4h 34m

2,240 km

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Cheapest month to fly from Medellin to Cusco

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. February 2027 $227
  2. April 2027 Cheapest $219

Cheapest dates in April 2027

The lowest fares we've seen for each day, cheapest first.

JetSmart
Depart17:25 Tue, Apr 27MDE → CUZ 4h 35m · 1 stop
$219one way, per person
View deal
JetSmart
Depart17:25 Thu, Apr 29MDE → CUZ 4h 35m · 1 stop
$219one way, per person
View deal
JetSmart
Depart17:25 Fri, Apr 30MDE → CUZ 4h 35m · 1 stop
$219one way, per person
View deal
JetSmart
Depart17:25 Sun, Apr 25MDE → CUZ 4h 35m · 1 stop
$223one way, per person
View deal
JetSmart
Depart17:25 Mon, Apr 26MDE → CUZ 4h 35m · 1 stop
$223one way, per person
View deal
JetSmart
Depart17:25 Wed, Apr 28MDE → CUZ 4h 35m · 1 stop
$223one way, per person
View deal
See every date in April 2027 →

Plan the rest of your trip to Cusco

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in CuscoCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in CuscoTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in CuscoPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in CuscoCompare rental cars from major brands on EconomyBookings Compare cars →

Stay connected

eSIM for PeruMobile data from the moment you land, by Airalo Get eSIM →

About flights from Medellin to Cusco

Medellin (MDE) and Cusco (CUZ) are about 2,240 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 4h 34m. Over the next few months, one-way fares start from $219, and April 2027 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Medellin to Cusco?

The cheapest one-way fare we've seen recently is $219 with JetSmart, departing Tuesday, April 27, 2027. Over the coming months, the lowest fare in each month ranges from $219 to $227.

What is the cheapest month to fly from Medellin to Cusco?

April 2027 currently has the lowest fares, from $219 one way.

Are there direct flights from Medellin to Cusco?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Medellin to Cusco?

The quickest journey we've seen takes about 4h 34m. Medellin and Cusco are around 2,240 km apart.

Which airlines fly from Medellin to Cusco?

Recent fares on this route were with JetSmart.

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