LATAM Airlines GroupDepart06:40
Fri, Nov 6MDE → GYE
3h 38m · 2 stops
$242one way, per person
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- Cheapest fare
- $242
- Cheapest month
- November
- Direct flights
- Not recently
- Quickest trip
- 3h 38m
LATAM Airlines Group · Fri, Nov 6
from $242
Usually 1+ stop
1,050 km
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Cheapest month to fly from Medellin to Guayaquil
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in November 2026
The lowest fares we've seen for each day, cheapest first.
See every date in November 2026 →Plan the rest of your trip to Guayaquil
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About flights from Medellin to Guayaquil
Medellin (MDE) and Guayaquil (GYE) are about 1,050 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 3h 38m. Over the next few months, one-way fares start from $242, and November 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Medellin to Guayaquil?
The cheapest one-way fare we've seen recently is $242 with LATAM Airlines Group, departing Friday, November 6, 2026.
What is the cheapest month to fly from Medellin to Guayaquil?
November 2026 currently has the lowest fares, from $242 one way.
Are there direct flights from Medellin to Guayaquil?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Medellin to Guayaquil?
The quickest journey we've seen takes about 3h 38m. Medellin and Guayaquil are around 1,050 km apart.
Which airlines fly from Medellin to Guayaquil?
Recent fares on this route were with LATAM Airlines Group.
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