Cheap flights from Medellin to Santo Domingo

One-way fares from $197 · MDE → SDQ · prices found by travellers in the last 48 hours

Cheapest fare
$197

Arajet · Sat, Nov 21

Cheapest month
November

from $197

Direct flights
Yes

Arajet

Flight time
2h 32m

1,490 km

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Cheapest month to fly from Medellin to Santo Domingo

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $197

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Arajet
Depart09:50 Sat, Nov 21MDE → SDQ 2h 32m · Direct
$197one way, per person
View deal
Arajet
Depart20:15 Wed, Nov 11MDE → SDQ 2h 32m · Direct
$232one way, per person
View deal
Arajet
Depart20:25 Mon, Nov 30MDE → SDQ 2h 32m · Direct
$245one way, per person
View deal
Arajet
Depart16:55 Tue, Nov 10MDE → SDQ 2h 32m · Direct
$263one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Santo Domingo

Where to stay, what to do and getting around, from our travel partners.

About flights from Medellin to Santo Domingo

Medellin (MDE) and Santo Domingo (SDQ) are about 1,490 km apart. Direct flights take around 2h 32m, and recent direct fares were with Arajet. Over the next few months, one-way fares start from $197, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Medellin to Santo Domingo?

The cheapest one-way fare we've seen recently is $197 with Arajet, departing Saturday, November 21, 2026.

What is the cheapest month to fly from Medellin to Santo Domingo?

November 2026 currently has the lowest fares, from $197 one way.

Are there direct flights from Medellin to Santo Domingo?

Yes. Recent direct fares were with Arajet.

How long is the flight from Medellin to Santo Domingo?

A direct flight takes about 2h 32m. Medellin and Santo Domingo are around 1,490 km apart.

Which airlines fly from Medellin to Santo Domingo?

Recent fares on this route were with Arajet.

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