Cheap flights from Santo Domingo to Medellin

One-way fares from $139 · SDQ → MDE · prices found by travellers in the last 48 hours

Cheapest fare
$139

Wingo · Sat, Nov 21

Cheapest month
November

from $139

Direct flights
Yes

Wingo and Arajet

Flight time
2h 30m

1,490 km

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Cheapest month to fly from Santo Domingo to Medellin

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $139
  2. December 2026 $175

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Wingo
Depart14:43 Sat, Nov 21SDQ → MDE 2h 30m · Direct
$139one way, per person
View deal
Arajet
Depart16:10 Sun, Nov 15SDQ → MDE 2h 30m · Direct
$173one way, per person
View deal
Arajet
Depart17:50 Wed, Nov 25SDQ → MDE 2h 30m · Direct
$179one way, per person
View deal
Arajet
Depart07:30 Fri, Nov 20SDQ → MDE 2h 30m · Direct
$206one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Medellin

Where to stay, what to do and getting around, from our travel partners.

About flights from Santo Domingo to Medellin

Santo Domingo (SDQ) and Medellin (MDE) are about 1,490 km apart. Direct flights take around 2h 30m, and recent direct fares were with Wingo and Arajet. Over the next few months, one-way fares start from $139, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santo Domingo to Medellin?

The cheapest one-way fare we've seen recently is $139 with Wingo, departing Saturday, November 21, 2026. Over the coming months, the lowest fare in each month ranges from $139 to $175.

What is the cheapest month to fly from Santo Domingo to Medellin?

November 2026 currently has the lowest fares, from $139 one way.

Are there direct flights from Santo Domingo to Medellin?

Yes. Recent direct fares were with Wingo and Arajet.

How long is the flight from Santo Domingo to Medellin?

A direct flight takes about 2h 30m. Santo Domingo and Medellin are around 1,490 km apart.

Which airlines fly from Santo Domingo to Medellin?

Recent fares on this route were with Wingo and Arajet.

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