Cheap flights from Santo Domingo to Panama City

One-way fares from $316 · SDQ → PTY · prices found by travellers in the last 48 hours

Compare all dates Panama City → Santo Domingo
Cheapest fare
$316

avianca airlines · Sat, Nov 14

Cheapest month
November

from $316

Direct flights
Yes

Copa Airlines

Flight time
2h 35m

1,480 km

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Cheapest month to fly from Santo Domingo to Panama City

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $316
  2. January 2027 $614
  3. March 2027 $324

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

avianca airlines
Depart12:45 Sat, Nov 14SDQ → PTY 4h 25m · 1 stop
$316one way, per person
View deal
See every date in November 2026 →

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Where to stay, what to do and getting around, from our travel partners.

Where to stay

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Things to do

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Getting around

Airport transfer in Panama CityPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Panama CityCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Santo Domingo to Panama City

Santo Domingo (SDQ) and Panama City (PTY) are about 1,480 km apart. Direct flights take around 2h 35m, and recent direct fares were with Copa Airlines. Over the next few months, one-way fares start from $316, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santo Domingo to Panama City?

The cheapest one-way fare we've seen recently is $316 with avianca airlines, departing Saturday, November 14, 2026. Over the coming months, the lowest fare in each month ranges from $316 to $614.

What is the cheapest month to fly from Santo Domingo to Panama City?

November 2026 currently has the lowest fares, from $316 one way.

Are there direct flights from Santo Domingo to Panama City?

Yes. Recent direct fares were with Copa Airlines.

How long is the flight from Santo Domingo to Panama City?

A direct flight takes about 2h 35m. Santo Domingo and Panama City are around 1,480 km apart.

Which airlines fly from Santo Domingo to Panama City?

Recent fares on this route were with avianca airlines and Copa Airlines.

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