Cheap flights from Panama City to Santo Domingo

One-way fares from $443 · PTY → SDQ · prices found by travellers in the last 48 hours

Compare all dates Santo Domingo → Panama City
Cheapest fare
$443

Copa Airlines · Thu, Nov 26

Cheapest month
November

from $443

Direct flights
Not recently

Usually 1+ stop

Quickest trip
4h 20m

1,480 km

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Cheapest month to fly from Panama City to Santo Domingo

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $443
  2. December 2026 $463
  3. January 2027 $492
  4. March 2027 $482

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Copa Airlines
Depart12:33 Thu, Nov 26PTY → SDQ 5h 26m · 1 stop
$443one way, per person
View deal
Copa Airlines
Depart08:16 Wed, Nov 11PTY → SDQ 5h 28m · 1 stop
$454one way, per person
View deal
Copa Airlines
Depart08:40 Wed, Nov 18PTY → SDQ 4h 20m · 1 stop
$464one way, per person
View deal
Copa Airlines
Depart18:15 Sat, Nov 14PTY → SDQ 5h 26m · 1 stop
$467one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Santo Domingo

Where to stay, what to do and getting around, from our travel partners.

Where to stay

Hotels in Santo DomingoCompare places to stay on Booking.com Find hotels →

Things to do

Things to do in Santo DomingoTours, attractions and day trips on Klook Explore →

Getting around

Airport transfer in Santo DomingoPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in Santo DomingoCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Panama City to Santo Domingo

Panama City (PTY) and Santo Domingo (SDQ) are about 1,480 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 4h 20m. Over the next few months, one-way fares start from $443, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Panama City to Santo Domingo?

The cheapest one-way fare we've seen recently is $443 with Copa Airlines, departing Thursday, November 26, 2026. Over the coming months, the lowest fare in each month ranges from $443 to $492.

What is the cheapest month to fly from Panama City to Santo Domingo?

November 2026 currently has the lowest fares, from $443 one way.

Are there direct flights from Panama City to Santo Domingo?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Panama City to Santo Domingo?

The quickest journey we've seen takes about 4h 20m. Panama City and Santo Domingo are around 1,480 km apart.

Which airlines fly from Panama City to Santo Domingo?

Recent fares on this route were with Copa Airlines and avianca airlines.

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