JetSmartDepart06:29
Thu, Nov 12ANF → SDE
5h 47m · 2 stops
$517one way, per person
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- Cheapest fare
- $517
- Cheapest month
- November
- Direct flights
- Not recently
- Quickest trip
- 5h 47m
JetSmart · Thu, Nov 12
from $517
Usually 1+ stop
770 km
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Cheapest month to fly from Antofagasta to Santiago Del Estero
Lowest one-way fare per person in each month. Choose a month to see every date.
Cheapest dates in November 2026
The lowest fares we've seen for each day, cheapest first.
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Where to stay, what to do and getting around, from our travel partners.
Getting around
About flights from Antofagasta to Santiago Del Estero
Antofagasta (ANF) and Santiago Del Estero (SDE) are about 770 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 5h 47m. Over the next few months, one-way fares start from $517, and November 2026 is currently the cheapest month to fly.
These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.
Frequently asked questions
How much is a flight from Antofagasta to Santiago Del Estero?
The cheapest one-way fare we've seen recently is $517 with JetSmart, departing Thursday, November 12, 2026.
What is the cheapest month to fly from Antofagasta to Santiago Del Estero?
November 2026 currently has the lowest fares, from $517 one way.
Are there direct flights from Antofagasta to Santiago Del Estero?
We haven't seen direct fares recently, so most journeys include at least one stop.
How long is the flight from Antofagasta to Santiago Del Estero?
The quickest journey we've seen takes about 5h 47m. Antofagasta and Santiago Del Estero are around 770 km apart.
Which airlines fly from Antofagasta to Santiago Del Estero?
Recent fares on this route were with JetSmart.
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