Cheap flights from Panama City to Guayaquil

One-way fares from $261 · PTY → GYE · prices found by travellers in the last 48 hours

Compare all dates Guayaquil → Panama City
Cheapest fare
$261

Copa Airlines · Mon, Nov 9

Cheapest month
November

from $261

Direct flights
Yes

Copa Airlines

Flight time
2h 16m

1,240 km

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Cheapest month to fly from Panama City to Guayaquil

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $261

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Copa Airlines
Depart09:02 Mon, Nov 9PTY → GYE 2h 16m · Direct
$261one way, per person
View deal
See every date in November 2026 →

Plan the rest of your trip to Guayaquil

Where to stay, what to do and getting around, from our travel partners.

Where to stay

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Things to do

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Getting around

Airport transfer in GuayaquilPre-book a driver to meet you at arrivals, with Kiwitaxi Book a transfer → Car hire in GuayaquilCompare rental cars from major brands on EconomyBookings Compare cars →

About flights from Panama City to Guayaquil

Panama City (PTY) and Guayaquil (GYE) are about 1,240 km apart. Direct flights take around 2h 16m, and recent direct fares were with Copa Airlines. Over the next few months, one-way fares start from $261, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Panama City to Guayaquil?

The cheapest one-way fare we've seen recently is $261 with Copa Airlines, departing Monday, November 9, 2026.

What is the cheapest month to fly from Panama City to Guayaquil?

November 2026 currently has the lowest fares, from $261 one way.

Are there direct flights from Panama City to Guayaquil?

Yes. Recent direct fares were with Copa Airlines.

How long is the flight from Panama City to Guayaquil?

A direct flight takes about 2h 16m. Panama City and Guayaquil are around 1,240 km apart.

Which airlines fly from Panama City to Guayaquil?

Recent fares on this route were with Copa Airlines.

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