Cheap flights from Santa Cruz to Cusco

One-way fares from $389 · SRZ → CUZ · prices found by travellers in the last 48 hours

Cheapest fare
$389

Boliviana de Aviación · Tue, Nov 10

Cheapest month
November

from $389

Direct flights
Not recently

Usually 1+ stop

Quickest trip
2h 20m

1,050 km

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Cheapest month to fly from Santa Cruz to Cusco

Lowest one-way fare per person in each month. Choose a month to see every date.

  1. November 2026 Cheapest $389

Cheapest dates in November 2026

The lowest fares we've seen for each day, cheapest first.

Boliviana de Aviación
Depart05:35 Tue, Nov 10VVI → CUZ 2h 20m · 1 stop
$389one way, per person
View deal
See every date in November 2026 →

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Where to stay, what to do and getting around, from our travel partners.

About flights from Santa Cruz to Cusco

Santa Cruz (SRZ) and Cusco (CUZ) are about 1,050 km apart. We haven't seen direct fares on this route recently, so expect at least one stop; the quickest journey we've seen takes about 2h 20m. Over the next few months, one-way fares start from $389, and November 2026 is currently the cheapest month to fly.

These prices come from searches travellers made in the last 48 hours, so they move quickly. If you see a good fare, it's worth booking soon. FlightsExp is free to use: you book directly with our travel partner.

Frequently asked questions

How much is a flight from Santa Cruz to Cusco?

The cheapest one-way fare we've seen recently is $389 with Boliviana de Aviación, departing Tuesday, November 10, 2026.

What is the cheapest month to fly from Santa Cruz to Cusco?

November 2026 currently has the lowest fares, from $389 one way.

Are there direct flights from Santa Cruz to Cusco?

We haven't seen direct fares recently, so most journeys include at least one stop.

How long is the flight from Santa Cruz to Cusco?

The quickest journey we've seen takes about 2h 20m. Santa Cruz and Cusco are around 1,050 km apart.

Which airlines fly from Santa Cruz to Cusco?

Recent fares on this route were with Boliviana de Aviación.

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